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Have a question about Soundbites?

Check out our answers here to customer questions about hearing preservation, tinnitus, Soundbites and the science behind it.

If you don’t find the answer you’re looking for, please write to us at hello@soundbites email. Our Customer Care team is supervised by a PhD MD. We answer questions promptly and confidentially. We may suggest that you follow up with an otologist, otolaryngologist, otoneurologist or audiologist.

What is Soundbites?

Soundbites is the first preventive care product for hearing to apply medical research on redox signaling biology[1].

Soundbites is a multi-patented cocktail of micronutrient antioxidants and a vasodilator mineral that preserves the life and health of irreplaceable inner ear nerve cells by defending them against free radical damage.

Soundbites is a scientifically complex but elegantly simple preventive care solution that’s safe for everyone. Please note children require a smaller dose and heavy smokers and those with lung cancer should consult their doctor before taking antioxidants.


  1. Forman, Henry Jay. “Redox signaling: An evolution from free radicals to aging.” Free radical biology & medicine vol. 97 (2016): 398-407. doi:10.1016/j.freeradbiomed.2016.07.003Fr

What is different between Soundbites and other Flavonoid ear ringing supplements?

First, flavonoids are often marketed as antioxidants, but research by the European Food Safety Authority (EFSA) and others suggests that flavonoids have negligible (5%) antioxidant absorption.

Second, one of the most-well known flavonoid products marketed for tinnitus dates from 1961. It contains flavonoid, principally; and also vitamin C; B-complex vitamins 1, 3, 6 and 12; choline bitartrate and inositol. Aside from vitamin C, we can find no demonstrated evidence that any of the other ingredients are beneficial for maintaining the structure and normal function of inner ear nerve cells.

Soundbites is different. The Soundbites micronutrient cocktail has the scientifically validated synergistic effect of preserving hearing by maintaining the normal function of inner ear nerve cells and promoting already scant inner ear blood flow. It also seems to help relieve tinnitus symptoms, which is a really cool positive side effect.

How can tinnitus start?

Scientists agree that hearing loss from any cause is highly connected to tinnitus, and that hearing loss can start with either short term or long term exposure to high intensity noise. Common examples are loud music at a live concert or in your earbuds every day. High intensity noise can cause inner ear sensory cell trauma, cell damage, cell death, temporary hearing loss, temporary tinnitus and permanent tinnitus.

Who gets tinnitus?

Anyone can get tinnitus at any age.

How many people have tinnitus?

If you have tinnitus you’re hardly alone. The US Centers for Disease Control and Prevention (CDC) estimates that about a third of the US population, 105 million people suffer from tinnitus.

The CDC also estimates that 70% and 85% of people with hearing loss have tinnitus, agreeing with scientists that tinnitus is highly connected with hearing loss. Hearing loss often increases with age, so prevalence of tinnitus is also likely to increase with age. But hearing loss data is far from perfect because historically, hearing loss has been viewed as an inevitable fact of aging, so collecting hearing data hasn’t been considered a health care priority. Consequently, we can’t rely on hearing loss data to give us an accurate picture of tinnitus, although we know many people with tinnitus have normal hearing.

What causes tinnitus?

Tinnitus, or ringing in the ears, is a symptom of a neurological disorder believed to be caused by the dysfunction of inner ear sensory neurons. Sensory neurons are nerve cells. Bundles of inner ear nerve cells called the spiral ganglia transmit sound to the brain. Tinnitus is believed to be caused by dysfunction in the spiral ganglia, combined with damage and death of hair cells, which are the hearing receptor cells in the inner ear.

Can tinnitus be cured?

Is there a cure for tinnitus?

Today, tinnitus is an incurable neurological disorder. Scientists don’t agree about what happens in the brain to create the illusion of sounds in the ear, but they do agree on two points that connect inner ear nerve damage to tinnitus.

First, exposure to high intensity noise causes temporary and permanent noise induced hearing loss (NIHL). NIHL is the most common type of sensorineural hearing loss (SNHL). SNHL causes damage and death of inner ear nerve cells. Second, SNHL is highly connected with tinnitus, so preventing SNHL also helps prevent tinnitus.

Tinnitus is a common symptom of hyperacusis. Hyperacusis is a neurological disorder that makes sounds seem louder or much louder than they really are. People with hyperacusis find it difficult to cope with normal sound levels.

What sounds do you hear with tinnitus?

Tinnitus sounds can vary in intensity from barely perceptible to mildly annoying to unbearably loud and completely debilitating. They can come and go, or persist for years or decades nonstop. The sounds themselves can vary in pitch, described as buzzing, ringing, whooshing or high to very high pitched continuous tone screeching.

Tinnitus sounds are nearly always subjective, meaning no one else can hear them. Objective pulsatile tinnitus is rare. The pulsing sounds associated with heartbeat, blood flow or breathing can be heard through a stethoscope.

Are there therapies for tinnitus?

There is no cure for tinnitus. Therapies focus on managing the symptoms and coping with the psychological impacts. There are no prescription pharmaceuticals for tinnitus. Doctors prescribe anti-anxiety drugs, antidepressants or steroids.

Soundbites thinks about tinnitus differently. We ’re a small, research-driven biomedical science company in the wellness business. We think preserving healthy hearing is the best strategy.

Soundbites blocks the biochemical triggers that damage inner ear nerves that cause tinnitus to start, preserving healthy hearing.

If you have tinnitus, Soundbites may relieve tinnitus symptoms by helping inner ear nerve cells work at a higher level of efficiency. Soundbites may not work for everyone, but the majority of our customers who report using it to manage tinnitus say it works for them. Results vary. Some customers don't perceive relief for 4 weeks, some after 6 weeks, some in 2 weeks, and some not at all. We believe our upcoming real world evidence studies will provide data that will help us learn much more.

What is the data on magnesium and cochlear blood flow?

Here’s a summary of some of the academic scholarship on magnesium and improved cochlear blood flow.

In summary, In most tissues, increased metabolism increases blood flow, which provides additional oxygen. However, intense stimulation of hair cells reduces blood vessel diameter and red blood cell velocity and thus decreases cochlear blood flow (Miller et al. 2002 [1]; for review, see Le Prell et al. 2007[2]. Reduced cochlear blood flow has significant implications for metabolic homeostasis, as cellular metabolism clearly depends on adequate supply of oxygen and nutrients as well as efficient elimination of waste products (e.g., Miller et al.1996).

Vasoconstriction in the cochlea is caused by the release of a powerful vasoconstrictor, the isoprostane 8-iso prostaglandin F2 alpha. In addition, the reduction in blood flow is followed by a rebound effect – an 'overshoot' – causing reperfusion injury-induced formation of additional free radicals, which synergistically add to those formed previously. Supplemental magnesium reduces vasoconstriction and reperfusion injury, which attenuates SNHL. (for review, see Le Prell et al. 2007 [2].)

In addition to well-known effects of magnesium on blood flow, other biochemical mechanisms may further contribute to the protective effects of Mg. Magnesium modulates calcium channel permeability, influx of calcium into cochlear hair cells, and glutamate release (Cevette et al. 2003 [3], Gunther et al. 1989 [4], each of which may reduce SNHL. Magnesium is also a NMDA-receptor antagonist. That the NMDA-receptor antagonist MK-801 reduces the effects of noise, ischemia, or ototoxic drugs (Janssen 1992 [5]; Basile et al 1996 [6]; Duan et al. 2000 [7]; Konig et al 2003 [8]; Ohinata et al 2003 [9], suggests another potential protective mechanism for Mg.


  1. Miller, Josef M.; Miller, Amy L.; Yamagata, Takahiko; Bredberg, Goran; Altschuler, Richard A. (2002). "Protection and regrowth of the auditory nerve after deafness: neurotrophins, antioxidants and depolarization are effective in vivo". Audiology & Neuro-Otology. 7 (3): 175–179. ISSN 1420-3030, PMID 12053141.
  2. Le Prell, Colleen G.; Hughes, Larry F.; Miller, Josef M. (2007-05-01). "Free radical scavengers, vitamins A, C, and E, plus magnesium reduces noise trauma". Free radical biology & medicine. 42 (9): 1454–1463. PMID 17395018.
  3. Michael J. Cevette, Jürgen Vormann, Kay Franz, Magnesium and Hearing, Journal of the American Academy of Audiology/Volume 14, Number 4, 2003 (pdf)
  4. Günther, T.; Ising, H.; Joachims, Z. (1989). "Biochemical mechanisms affecting susceptibility to noise-induced hearing loss". The American Journal of Otology. 10 (1): 36–41. ISSN 0192-9763, PMID 2655464.
  5. Janssen, R. (1992-09-11). "Glutamate neurotoxicity in the developing rat cochlea is antagonized by kynurenic acid and MK-801". Brain Research. 590 (1–2): 201–206. ISSN 0006-8993. PMID 1358402.
  6. Basile, A. S.; Huang, J. M.; Xie, C.; Webster, D.; Berlin, C.; Skolnick, P. (1996). "N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss". Nature Medicine. 2 (12): 1338–1343. ISSN 1078-8956, PMID 8946832.
  7. Duan, M.; Agerman, K.; Ernfors, P.; Canlon, B. (2000-06-20). "Complementary roles of neurotrophin 3 and a N-methyl-D-aspartate antagonist in the protection of noise and aminoglycoside-induced ototoxicity". Proceedings of the National Academy of Sciences of the United States of America. 97 (13): 7597–7602. ISSN 0027-8424, PMID 10861021.
  8. König, Ovidiu; Winter, Elisabeth; Fuchs, Julia; Haupt, Heidemarie; Mazurek, Birgit; Weber, Nina; Gross, Johann (2003). "Protective effect of magnesium and MK 801 on hypoxia-induced hair cell loss in new-born rat cochlea". Magnesium Research. 16 (2): 98–105. ISSN 0953-1424, PMID 12892379.
  9. Ohinata, Yoshimitsu; Miller, Josef M.; Schacht, Jochen (2003-03-21). "Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea". Brain Research. 966 (2): 265–273. ISSN 0006-8993, PMID 12618349.

What are the active ingredients in Soundbites?

Soundbites, known as ACEMg in about two dozen peer reviewed medical research articles published starting in 2007, is a cocktail containing four micronutrients: β-carotene – vitamin A; Ascorbic acid – vitamin C; Trolox – vitamin E; and the mineral magnesium. The ingredients in the cocktail work together synergistically to do what none of the ingredients can do without the others. That synergy is the basis for all the issued patents. The ACE vitamins work in specific parts of inner ear nerve cells to neutralize free radicals. The Mg works as a vasodilator primarily in inner ear blood vessels to promote inner ear blood flow.

The following plumbing analogy might seem a bit gross, but it works well enough to illustrate the basic principle. Exposure to intense noise produces an overload of excess cellular waste. The micronutrients work like a disinfectant to neutralize and package up that waste. The Mg keeps the pipes open, so the blood can carry the waste away.

Analogies always fail at some point, and this one fails because plumbing pipes can clog, but they can’t squeeze shut. Inner ear blood vessels can squeeze shut, and when they do, reduced inner ear blood flow causes ischemia reperfusion injury, similar to having a heart attack or a stroke in the inner ear. That is not an exaggeration. The Mg in Soundbites keeps inner ear blood vessels from squeezing shut.

Will Soundbites bring back my hearing?

No. Soundbites will not bring back hearing you have lost. Restoring hearing requires regenerating hearing cells. Hearing cells in humans do not regenerate. Soundbites does not restore hearing or grow new hearing cells. Although research is ongoing, medical science does not offer those possibilities at the moment.

What does Soundbites do?

Soundbites is designed to help you keep the hearing you have by doing two things at once. Soundbites provides a patented combination of the precise antioxidant micronutrients inner ear cells need to help neutralize the excess free radicals that damage hearing cells, and a mineral that promotes inner ear blood flow, blocking the ‘choke-and-release’ damage caused by the vasoconstrictor isoprostane 8-iso prostaglandin F2a. Together, the formulation maintains normal auditory function.

Will I experience a difference in my hearing when taking Soundbites?

How can I tell if Soundbites is working?

Hearing function is affected by a wide variety of factors including your age, genetics, lifestyle and life quality like nutrition. At any age, Soundbites helps your hearing cells work the way they’re supposed to work, free of oxidative stress that compromises normal auditory function and damages hearing. To tell if Soundbites is working, we suggest taking it daily for at least 4 weeks, then stop for two weeks and see if you notice differences. We suggest this test because differences, if any, will likely be gradual, and you may not notice them until after you stop.

Soundbites helps eliminate inner ear oxidative stress and maintain good inner ear blood flow so your hearing cells stay healthy and function normally. You may perceive differences that accompany reduction of oxidative stress in a shorter time if your ears are under a high degree of oxidative stress, but we cannot claim you will perceive any differences in your hearing or tinnitus symptoms, or improvement in your hearing acuity.

What if I wear hearing aids or have cochlear implants?

Will Soundbites help if I wear hearing aids or have cochlear implants?

Hearing aids of all types and cochlear implants amplify sound for those with mild to profound hearing disability. Soundbites helps maintain normal auditory function of hearing cells, regardless of how sound gets to your inner ear, or the level of your hearing impairment or disability.

If you rely on these devices, your doctor likely administers hearing tests using pure tone audiometry to help calibrate your device. Please tell your doctor or audiologist that you are using Soundbites, and start reviewing your audiograms to assess measurable effects over time on your hearing profile and preservation of your residual hearing that may be due to taking Soundbites. Doctors prefer reading source material. Click here for the Soundbites white paper with links to all the peer reviewed papers.

I use noise cancelling earbuds because I’m really aware of hearing damage from world noise. Should I be using soundbites too?

Sould I take Soundbites if I use noise cancelling earbuds?

You’re right to be concerned. World noise is a major contributor to hearing loss, and the problem is increasing rapidly. Noise cancellation technologies can be very effective at reducing or blocking damaging noise levels. We encourage all hearing protection devices in addition to Soundbites because Soundbites works when not you’re wearing hearing protection and it provides an extra cushion of safety when you are. Soundbites is not intended to replace hearing protection devices, nor is it intended as a free pass to take risks with your hearing.

Is there a connection between hearing loss from aging and hearing loss from exposure to intense sound and noise?

Yes. Age-related hearing loss and noise-induced hearing loss are the two most common types of SNHL – sensorineural hearing loss - hearing loss caused by the death of inner ear nerve cells. The root cause is the same: oxidative stress caused by excess inner ear free radicals. Hearing cells tend to produce additional free radicals as they age, moreso when they are damaged. Conventional wisdom is that age-related hearing loss happens to older people, but that is not accurate. Age related hearing loss can happen at any age, mainly because of the exposure to intense levels of sound and noise, which also accelerates hearing loss. An estimated 12.5% of children and adolescents aged 6–19 years (approximately 5.2 million) have suffered permanent damage to their hearing from excessive exposure to noise (US Centers for Disease Control and Prevention).

When do I take soundbites?

Take Soundbites any time of the day that works for you. Noise induced hearing loss – hearing loss caused by world noise – is the fastest growing cause of hearing loss. We suggest taking Soundbites daily as part of your regular healthcare routine if you are persistently exposed to noise in your work environment, if you live with world noise, if you use earbuds or headphones in loud environments, or if you are simply concerned about keeping the hearing you have, regardless of your age. Think of Soundbites as preventive care for your hearing much like toothpaste is preventive care against cavities.

If you choose to take Soundbites infrequently, we suggest taking before you are exposed to loud noise in environments such as entertainment venues, live sports venues, during airline travel, or when working with loud power tools or sporting equipment.

If you forget to take Soundbites in advance of exposure to intense sound or noise, take Soundbites as soon as possible after exposure, and continue for at least three days to help your hearing cells recover.

Is Soundbites safe?

Yes. The ingredients in Soundbites are classified by the FDA as Generally Regarded as Safe (GRAS). The safety of micronutrient supplements – vitamins and minerals – has been researched since the first vitamins were discovered about 100 years ago. Soundbites softgel capsules are suitable for ages 9 and up.

Heavy smokers should consult their doctor before taking antioxidants, especially vitamin A.

Young children need a lower dose. A low-dose form of Soundbites has been developed for doctors treating children with clinical indications of free radical-induced hearing impairment including GJB2/connexin 26 genetic mutation; aminoglycoside ototoxicity; and congenital cytomegalovirus (cCMV).

I take vitamins already. Will that do the trick?

It depends on what you take. Many people already take antioxidant vitamin supplements to help eliminate oxidative stress. Soundbites is scientifically validated to deliver the exact antioxidants and vasodilator mineral that inner ear nerve cells need to relieve the oxidative stress that damages hearing and causes hearing loss.The dose is higher than what is available in most multivitamin supplements, but still within the safe upper limit of daily intake, even if you already take a multivitamin supplement.

Is Soundbites a drug?

No. Soundbites is a nutritional supplement. It is not a drug. Soundbites does not require a medical prescription nor side-effect monitoring.

I use earbuds and headphones. Am I hurting my hearing? Should I use soundbites?

Are headphones hurting my hearing? Are earbuds huring my hearing? Should I use Soundbites if I use headphones?

It’s difficult to know. Consumer tech for sound level monitoring is just starting to appear, but it’s virtually impossible for most people to know if the combination of listening time and volume are within safe limits. You may want to consider using Soundbites if you use any personal listening device for long periods or at loud volumes, including earbuds, headphones, even hearing aids or cochlear implants. But please think of Soundbites as preventive care insurance and not as a free pass to take risks by turning up the volume.

Will there be other preventive treatments?

Many pharmaceuticals are in development. None are on the market yet. If and when they become available, they will require prescription and physician monitoring of side effects. At least some may require physician procedures.

Is it normal that I’m losing my hearing as I get older? Is it related to hearing damage from listening to loud music when i was younger, or living in a city, or what?

Is it normal that I’m losing my hearing as I get older? Is hearing loss related to hearing damage from listening to loud music? Is hearing loss related to living in a city?

Age-related hearing loss (ARHL) and noise-induced hearing loss, or NIHL, are linked. Listening to loud music contributes to noise-induced hearing loss, and NIHL contributes between 25% and 50% of the burden of ARHL. In other words, NIHL speeds up ARHL and contributes to making it worse. But listening to loud music is not the only cause of NIHL. World noise is also a big contributor.

Urban environments are increasingly noisy. A majority of the world’s population now lives in cities, and hearing loss is happening to many more people earlier in life.

In 1800, only 3 percent of the world’s population lived in cities. By 1900, almost 14 percent lived in cities; 30 percent by 1950. In 2008, for the first time, the world’s population was evenly split between urban and rural areas. More developed nations were about 74 percent urban. Now urbanization is occurring more rapidly in many less developed countries.

It is expected that 70 percent of the world population will be urban by 2050, and most urban growth will occur in less developed countries. All of this means that an increasing percentage of the world’s population will suffer hearing loss in the coming years and decades.

If trends continue without interventions like Soundbites, it's estimated that 10% of the world population, or 1 billion people, will be functionally deaf by 2050.

Are there any discoveries or statistics about the effect of Soundbites on chronic kidney disease patients and sudden sensorineural hearing loss (SSNHL) due to dialysis?

Is it okay to take Soundbites if you have chronic kidney disease? Is it okay to take Soundbites if you have CKD?

The micronutrients in Soundbites – antioxidant vitamins A, C, E and the mineral magnesium – are classified by the FDA as “Generally Regarded As Safe” (GRAS).

To our knowledge, there are no discoveries, statistics or studies concerning Soundbites and chronic kidney disease (CKD), so unfortunately we can’t offer any guidance on that topic. Your doctor is your best route to answers about micronutrients and CKD. The National Kidney Foundation website indicates that CKD patients may need to avoid vitamins A, E, K and perhaps vitamin C.

The research indicates that SSNHL affects CKD patients more frequently than non-CKD patients. If you are a CKD patient experiencing SSNHL, we urge you to contact your doctor immediately, and start taking Soundbites immediately unless your doctor advises against it for the reasons stated by the National Kidney Foundation cited above.

How long before Soundbites will begin to reduce ear ringing?

How long before Soundbites starts reducing tinnitus?

Here’s what we know anecdotally from customer reports.

Temporary tinnitus is defined as lasting less than six months. Soundbites works to reduce temporary tinnitus symptoms within 30 minutes after taking it. It works best to take Soundbites before exposure to sound or noise levels loud enough to cause temporary tinnitus, or within three days of that exposure.

Permanent tinnitus is defined as tinnitus that lasts longer than six months. Soundbites can help relieve symptoms of permanent tinnitus too, but unfortunately, it is currently impossible to know who Soundbites will help, or how long it might take to notice. For some with permanent tinnitus, Soundbites works within a few weeks. Others take Soundbites for 6 weeks or longer before they perceive relief. Unfortunately, some with permanent tinnitus perceive no relief.

Many of those with permanent tinnitus also have permanent hearing loss. The feedback is similar. Some notice improved hearing acuity – sharpness or keenness – which, for example, makes it easier to understand conversation with the person next to you in a crowd (those days will return) – an indication that hearing cells are under less oxidative stress and working better, but it doesn’t mean hearing cells have grown back. Some notice this improvement within a month, others within two months, and some don’t notice at all.

Can Soundbites reduce metallosis-induced tinnitus from failed joint replacements?

There is much more to learn about tinnitus, and Soundbites customers are teaching us and others about its varied forms. Here’s a recent example.

A Soundbites customer has been suffering with metallosis-induced tinnitus for about a decade. The tinnitus was caused by free-floating Chromium (Cr) and Cobalt (Co) cations from a failed joint replacement. Thousands of others also suffer as she does. She reports that Soundbites really helps her. “The ringing is softer and easier to ignore,” she says.

A cation (say "cat ion") is a positively charged ion. Metallosis is the accumulation of cations from metal debris in the soft tissues of the body. Our review of the research indicates that Co and Cr metallosis toxicity is due at least in part to the ability of Co to stabilize hypoxia inducible factor (HIF) and mimic hypoxia, a condition where tissues and cells are deprived of adequate oxygen supply. Hypoxia is a root cause of sensorineural hearing loss (SNHL), and SNHL is highly correlated with tinnitus. Co and especially Cr are divalent cations, as is Magnesium (Mg), so it could be that Mg is displacing the Cr or Co in hair cells, or blocking their action in some other way. Research in rats shows damage to both hair cells and the spiral ganglion cochlear nerve cells, especially from Co.

It is perfectly logical to think that Soundbites would be helpful in mitigating divalent cation poisoning, but that can only be proved in real world evidence studies of people who suffer this troubling variant of tinnitus. So far we have one case report.

Are there any known side effects from taking this medication?

Is Soundbites the same as ACEMg? Does Soundbites interact with drugs? Is Soundbites safe for children? Is Soundbites a drug?

Soundbites is a multi-patented antioxidant-plus-vasodilator formulation of four micronutrients – β-carotene (converted in the body to vitamin A), ascorbic acid (vitamin C), trolox (vitamin E) and the vasodilator magnesium (Mg).

Soundbites is a nutritional supplement. Soundbites is not a prescription drug. Soundbites is produced in compliance with FDA Good Manufacturing Practices (GMP) and complies with FDA Dietary Supplements Health and Education Act (DSHEA) regulations. These statements have not been evaluated by the FDA. Soundbites is not intended to diagnose, cure, treat or prevent any disease. However, hearing loss is a metabolic stress disorder, not a disease. Tinnitus and hyperacusis are neurological disorders, not diseases.

The adult daily dose of each micronutrient in Soundbites is higher than the RDI (recommended daily intake) but lower than the UL (upper limit). There is no indication that Soundbites interacts with pharmaceuticals, and there are no side effects from taking Soundbites. Cigarette smokers and those with lung cancer are encouraged to consult a doctor before taking supplemental vitamin A. Children under 9 years of age require a smaller dose than contained in Soundbites one softgel capsule (contact and we’ll send you a dosing chart and instructions).

The Soundbites formula is known in the peer reviewed medical literature as ACEMg with the 2007 publication of the peer reviewed paper disclosing the formula and demonstrating its unexpected synergistic beneficial effect of maintaining normal auditory function when noise intensity increases by 30 dB, and to reduce inner ear pathology for noise by 75% (Le Prell et al, 2007) [1].


  1. Le Prell, Colleen G.; Hughes, Larry F.; Miller, Josef M. (2007-05-01). "Free radical scavengers, vitamins A, C, and E, plus magnesium reduces noise trauma". Free radical biology & medicine. 42 (9): 1454–1463. doi:10.1016/j.freeradbiomed.2007.02.008. ISSN 0891-5849. PMC 1950331. PMID 17395018.

Have there been placebo controlled clinical trials done showing efficacy of Soundbites?

What about real world studies?

Soundbites was developed to preserve hearing. Today, it is settled science that the root cause of sensorineural hearing loss (SNHL) is oxidative stress triggered by excess inner ear free radicals, and that Soundbites blocks its root cause.

Clinical researchers have been unable to design placebo controlled clinical trials that mimic real world noise exposures known to cause SNHL because it is medically unethical to cause harm in a placebo controlled trial. This is a problem for all potential hearing preservation therapeutics.

However, Soundbites customers have discovered that Soundbites also works to reduce symptoms of tinnitus and hyperacusis. This unexpected but obviously good news creates new research possibilities. New customers want to know if Soundbites will help them, and if so, how long it might take to notice.

User-centered real world studies are the way to answer these questions. We can ask individuals to compare their perceptions before and after taking Soundbites as they go about daily life. We’re working on those studies now with the Keep Hearing nonprofit.

I have osteoporosis – weakened bones. Does the Magnesium in Soundbites help or hurt those with osteoporosis?

The research indicates that for osteoporosis, more Magnesium is better than less. The following excerpts are from the scholarly article cited below. Definitions have been added in [brackets].

Bones of Mg deficient animals are brittle and fragile....It is also relevant that Mg restriction promotes oxidative stress, partly as a consequence of inflammation partly because of the reduced anti-oxidant defenses which occur upon Mg restriction. The increased amounts of free radicals potentiate the activity of osteoclasts [bone cells that absorb bone tissue during growth and healing] and depress that of osteoblasts [cells that secrete the components for bone formation].

A last issue that is overlooked in experimental models is about the vasculature in the bone of Mg deficient animals. An adequate blood supply is necessary for bone health. Interestingly, decreased intraosseous blood vessel volume and number [situated within, occurring within, or administered by entering a bone] seems to be relevant in the development of post-nerve-injury osteoporosis and in old-age associated osteoporosis.

Overall, all experimental data from animal studies indicate that reduced dietary intake of Mg is a risk factor for osteoporosis through a constellation of different mechanisms.


  1. Castiglioni, Sara et al. “Magnesium and osteoporosis: current state of knowledge and future research directions.” Nutrients vol. 5,8 3022-33. 31 Jul. 2013, doi:10.3390/nu5083022

Can I take Soundbites if I take medication for high blood pressure (HBP or HP)?

Can I take Soundbites if I take medication for fast heart rate?Can I take Soundbites if I take medication for fast heartbeat?

As general rule,the micronutrients in Soundbites don’t interfere with prescription medications – pharmaceutical drugs.

Specifically, with respect to blood pressure and heartbeat medications, it’s all good news. Fast heartbeat medications are beta blockers. Soundbites is safe to take with beta blockers. With respect to blood pressure medications, a...“[c]omprehensive analytical review of 44 human studies in 43 publications of oral Magnesium (Mg) therapy for hypertension (HT) shows Mg supplements may enhance the blood-pressure (BP) lowering effect of anti-hypertensive medications.”

This means the Magnesium in Soundbites may potentiate the effectiveness (increase the power or effect) of some anti-hypertensive medications. Consultation with your prescriber is recommended.


  1. A.Rosanoff, “Magnesium supplements may enhance the effect of antihypertensive medications in stage 1 hypertensive subjects”,Magnesium Research, 2010 Mar;23(1):27-40. doi: 10.1684/mrh.2010.0198. Epub 2010 Mar 12. PMID: 20228010

Can you guarantee results for tinnitus sufferers?

What is an N-of-1 study?

Soundbites was designed to preserve hearing. Evidence provided by Soundbites customers over the past several years indicates that Soundbites also helps reduce symptoms of permanent tinnitus for some. That's good news, but unfortunately it's not currently possible to know who Soundbites will help, or how long it might take for you to notice.

For some with permanent tinnitus, Soundbites works within a few weeks. Others take Soundbites for 6 weeks or longer before they perceive relief. Unfortunately, some with permanent tinnitus perceive no relief.

The Soundbites real world study, in development with the Keep Hearing nonprofit, is intended to provide answers for those who suffer tinnitus and other hearing disorders, but results are unlikely to be available until 2021. In the meantime, if you decide to try Soundbites you can conduct your own N-of-1 trial to find out if Soundbites helps you. N-of-1 is the term for a clinical study with one participant – you – taking an active intervention and reporting.

If you suffer with tinnitus, hyperacusis, genetic hearing loss, a pharmaceutically- or medically-induced hearing disorder, or a medical condition where hearing loss is a side effect, please keep in mind what Dr. Green has said as you use Sounbites. Although the effects of Soundbites are often not dramatic in the short run, these real changes are clinically important over time. Sharing your experience while using Soundbites will add case report data that may help others. Please write and tell us. Your privacy is guaranteed. We anonymize all reports when sharing publicly.

What makes Soundbites different from a pharmaceutical company?

First, Soundbites is small and independent.

Second, pharmaceutical companies primarily make drugs for disease management and treatment. There are no specialized drugs to treat hearing loss or tinnitus, and anyway, these are metabolic stress disorders, not diseases. Doctors sometimes use all-purpose drugs like corticosteroids to attempt treating hearing loss and other hearing disorders, but steroids and all other drugs must be prescribed by a licensed professional because they have side effects which need to be monitored. Soundbites is safe. No side-effect monitoring is needed.

Third and most importantly, Soundbites is the result of medical R&D funded primarily through government grants in the US and Europe by taxpayers, not shareholders. Soundbites is repaying that public support though its public benefit mission, conducted in alliance with the Keep Hearing nonprofit, to reduce the huge global social and economic costs associated with hearing impairment by educating, conducting research and providing equal access to Soundbites.

The RDA of vitamin A is 900 mcg RAE. Is 9000 a safe dose?

The recommended dietary allowance (RDA) for vitamin A is 900 mcg for men, 700 mcg for women. However, the vitamin A in the ACEMg formula is beta carotene, the provitamin A. There is no RDA for beta carotene, and no upper intake level (UL), because our bodies convert beta carotene into vitamin A as it’s needed. Studies of beta carotene have used daily doses up to 180 mg with no adverse effects. Further, there is no difference between naturally occurring or chemically synthesized beta carotene.

Importantly, for the purpose of hearing preservation, beta carotene can also act as a lipid radical scavenger and as a singlet oxygen neutralizer. Singlet oxygen is a free radical. Cells, including inner ear nerve cells, convert beta carotene into vitamin A to scavenge and neutralize excess free radicals occurring in their lipid (fat) compartments.


  1. Grune, T., Lietz, G., Palou, A., Ross, A. C., Stahl, W., Tang, G., Thurnham, D., Yin, S. A., & Biesalski, H. K. (2010). Beta-carotene is an important vitamin A source for humans. The Journal of nutrition, 140(12), 2268S–2285S.
  2. Zhao, L., Zhang, Q., Zheng, J. et al. Dietary, circulating beta-carotene and risk of all-cause mortality: a meta-analysis from prospective studies. Sci Rep 6, 26983 (2016).

Can you explain the current state of the art in tinnitus research and how Soundbites fits in?

Tinnitus is a neurological disorder – incurable brain noise. The perceived sounds are generated in the auditory cortex, not in the inner ear. Although some who suffer tinnitus have normal hearing, the scientific consensus is that hearing loss is the main contributor to tinnitus.

A recent tinnitus research review article – Pathophysiology of Subjective Tinnitus: Triggers and Maintenance – summmarizes the state of the art on tinnitus research.[1] Reducing spontaneous noise generation in the central auditory cortex in the brain is the hypothesis driving electromagnetic stimulation therapies including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). These therapies aim to reduce brain cell activity by delivering tiny amounts of electricity to the skin aiming to reduce brain cell activity. There is no convincing evidence that this works. Another approach to reducing noise generation in the brain is to use sound therapies to mask the noise of tinnitus, typically by using wearable or external devices that distract overactive brain cells. Masker therapies are safe, typically require long-term time commitments and are somewhat effective.

Our hypothesis is that spontaneous noise generation in the central system can be reduced by decreasing the level of over-excitation of afferent neurons in the peripheral system (the inner ear). We extend that hypothesis to include stereocilia cells. Our approach to accomplishing the reduction in central auditory cortex sound-generating activity is to administer the Soundbites micronutrient formula orally. The formula provides the mitochondria of afferent nerve cells and stereocilia cells with the precise supplementation they require to continue functioning normally, especially when these cells would otherwise be under hypoxia-generated stress that causes irreversible, lifelong downstream auditory problems including, but not limited to tinnitus.

The conclusion in the review article appears to validate the Soundbites approach: "The current view on tinnitus therefore is that it is a symptom encompassing a distributed network across the peripheral and central auditory system. Many studies would indicate that the restoration of cochlear output to the brain should also abolish tinnitus. Preliminary evidence reporting benefit from hearing aids and cochlear implants for tinnitus support this view."

In other words, hearing preservation is the route to ending tinnitus.


  1. Haider Haúla Faruk, Bojić Tijana, Ribeiro Sara F., Paço João, Hall Deborah A., Szczepek Agnieszka J., "Pathophysiology of Subjective Tinnitus: Triggers and Maintenance", Frontiers in Neuroscience, Vol. 12, 2018,, DOI 10.3389/fnins.2018.00866, ISSN 1662-453X.

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